These medicines can't be combined with SSRIs or other medicines that increase serotonin. Selegiline (Emsam), an MAOI that you stick on your skin as a patch, may cause fewer side effects than other MAOIs. Using an MAOI requires a strict diet because of dangerous (or even deadly) interactions with foods that contain tyramine - such as certain cheeses, pickles and wines - and some medicines, including pain medicines, decongestants and certain herbal supplements. This is because they can have serious side effects. MAOIs - such as tranylcypromine (Parnate), phenelzine (Nardil) and isocarboxazid (Marplan) - may be prescribed, often when other medicines haven't worked. So tricyclic antidepressants generally aren't prescribed unless you've tried other antidepressants first without improvement. Tricyclic antidepressants - such as imipramine, nortriptyline (Pamelor), amitriptyline, doxepin and desipramine (Norpramin) - tend to cause more side effects than newer antidepressants. Bupropion is one of the few antidepressants not frequently associated with sexual side effects. More-commonly prescribed antidepressants in this category include trazodone, mirtazapine (Remeron), vortioxetine (Trintellix), vilazodone (Viibryd) and bupropion (Forfivo XL, Wellbutrin SR, others). These antidepressants are called atypical because they don't fit neatly into any of the other antidepressant categories. Examples of SNRIs include duloxetine (Cymbalta, Drizalma Sprinkle), venlafaxine (Effexor XR), desvenlafaxine (Pristiq) and levomilnacipran (Fetzima).
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